Endocrine Abstracts

Aim: The aim of the study was the evaluation of the relationship between thyroid size and the result of radioactive iodine therapy in patients treated due to Graves’ hyperthyroidism.Material and methods: The study group included 150 subjects (127 M and 23 F), aged from 20 to 78 years (mean 48.33 years) at the moment of 131I therapy.In all patients the thyroid technetium-99m scan and determination of the serum levels...

Adiposity predisposes to insulin resistance and type II diabetes. Adipose tissue is an active endocrine organ, secreting adipokines with important physiological actions. Adiponectin is a recently discovered adipokine whose levels are, paradoxically, decreased in obesity despite the increase in adipocyte mass. Adiponectin suppresses triglyceride accumulation, increases fatty acid oxidation and activates AMP kinase (AMPK) in skeletal muscle, improving insulin signalling, and it ...

Background: The lack of circadian rhythm is a marker of Cushing’s syndrome (CS). Therefore, salivary cortisol rhythm has been suggested for studies on the hypothalamic–pituitary–adrenal (HPA) axis. Late-night salivary cortisol has been used recently by many centers as a first line diagnostic test for CS, yet its accuracy is still on debate.Aim: To evaluated the performance of morning and late night salivary cortisol in patients with CS and...

Introduction: Hyperparathyroidism is a disease characterized by excessive secretion of parathyroid hormone (PTH). There are three main etiologies: primary (PHPT), secondary (SHPT) and tertiary hyperparathyroidism (THPT). PHPT is characterized by abnormal regulation of PTH secretion by calcium, resulting in hypersecretion of PTH relative to the serum calcium concentration. SHPT is the overproduction of PTH in context of hypocalcemia, most frequently because of vitamin D deficie...

Backgroud: Primary hyperparathyroidism is the most common cause of hypercalcemia, which is associated with an increased frequency of hypertension. However, there are no data on the prevalence of primary hyperparathyroidism in patients who present with hypertension.Clinical case: We present the case of a 40-year-old woman with a history of hypertension for ten years. In 2017 she was referred for evaluation of hypercalcemia. The patient denied any symptoms...

Section 1: Case history: A 30-year-old Romanian male presented to A&E with symptomatic hypoglycaemia (point-of-care venous glucose 1.8 mmol/l, laboratory value 2.0). He reported 2 days of intermittent left-sided abdominal pain and frequent food craving. Despite eating, he developed dysarthria, hyperhidrosis, somnolence and asthenia, associated with epigastric pain and vomiting. He was recently diagnosed with hepatitis C, discovered incidentally during investigations for ch...

Background: Graves’ disease (GD) is the most common form of hyperthyroidism in Sweden. About 2000 patients are affected by GD annually (incidence 21/100 000) and a majority are women in working age. GD can be overwhelming for the affected patient. Health care professionals do their best to meet the patients’ needs, but can we do more? The aim of this study was to explore patients’ experiences of being affected by GD to improve healthcare.M...

Background: Childhood obesity is increasing worldwide and presents as a global health issue due to multiple metabolic comorbidities. About 1% of adolescents with obesity develop type 2 diabetes (T2D), however little is known about the genetic background in young age. The objective of this study was to assess the prevalence of impaired glucose regulation (IGR) in a large cohort of children and adolescents with obesity and to characterize insulin sensitivity and insulin secretio...

Background: Most women with androgen excess have polycystic ovary syndrome (PCOS); however, rarer pathology is considered in a severe phenotype such as ovarian or adrenal androgen-producing tumours. Simultaneous adrenal and ovarian vein sampling is rarely performed to aid the localisation of the androgen excess source. We report four cases that underwent this procedure.Case descriptions: Case 1: A 27-yea...

Introduction: Our case is a young couple, both endocrinologically monitored from childhood. Woman with diagnosis of oligomenorrhea – secondary amenorrhea. Man with delayed puberty. After complex endocrinological screening both diagnoses was changed to: woman diagnosed with prolactinoma and man with isolated idiopathic central hypogonadism (IICH). They were trying to concieve for 10 years with no succes.Case: Woman: At 17 years of age diagno...